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Effects of a topical botanically-enriched salve on cutaneous oxygenation.
Journal of wound care
  • Jamie Corroon
  • Ryan Bradley
  • Andrew Erlandsen
  • Jan Taylor
  • Doug Hanes, Providence / Helfgott Research Institute, National University of Natural Medicine, Portland, US
Document Type
Publication Date
  • Administration, Cutaneous,
  • Cross-Over Studies,
  • Diabetes Mellitus, Type 2,
  • Diabetic Foot,
  • Double-Blind Method,
  • Female,
  • Humans,
  • Male,
  • Middle Aged,
  • Ointments,
  • Oxygen,
  • Plant Extracts,
  • Skin,
  • Treatment Outcome,
  • Wound Healing

OBJECTIVE: There is a medical need to evaluate new treatments that may improve wound healing. This study aimed to determine if Original Healing Salve (OHS, Puremedy, Inc.) a topical, botanically-enriched salve (BES), changes distal leg tissue oxygenation in people with type 2 diabetes.

METHOD: A randomised, controlled, crossover, double-blinded clinical trial comparing changes in cutaneous oxygen delivery (mean TcPO

RESULTS: A total of 16 participants were recruited. Analysis of the primary outcome demonstrated no statistically significant difference in TcPO

CONCLUSION: These findings support consideration of topical treatments containing botanical ingredients to increase cutaneous oxygen delivery in the lower extremity in patients with type 2 diabetes.

Clinical Institute
Kidney & Diabetes
Citation Information
Jamie Corroon, Ryan Bradley, Andrew Erlandsen, Jan Taylor, et al.. "Effects of a topical botanically-enriched salve on cutaneous oxygenation." Journal of wound care (2019)
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