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Article
Traumatic brain injury: classification, models, and markers.
Biochemistry and Cell Biology / Biochimie et Biologie Cellulaire
  • Dema Najem
  • Kerry Rennie
  • Maria Ribecco-Lutkiewicz
  • Dao Ly
  • Julie Haukenfrers
  • Qing Liu
  • Munyao Nzau
  • Douglas D Fraser, Western University
  • Mahmud Bani-Yaghoub
Document Type
Article
Publication Date
8-1-2018
URL with Digital Object Identifier
https://doi.org/10.1139/bcb-2016-0160
Disciplines
Abstract

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to its high incidence rate and often long-term sequelae, TBI contributes significantly to increasing costs of health care expenditures annually. Unfortunately, advances in the field have been stifled by patient and injury heterogeneity that pose a major challenge in TBI prevention, diagnosis, and treatment. In this review, we briefly discuss the causes of TBI, followed by its prevalence, classification, and pathophysiology. The current imaging detection methods and animal models used to study brain injury are examined. We discuss the potential use of molecular markers in detecting and monitoring the progression of TBI, with particular emphasis on microRNAs as a novel class of molecular modulators of injury and its repair in the neural tissue.

Notes

Article available at Biochemistry and Cell Biology / Biochimie et Biologie Cellulaire

https://doi.org/10.1139/bcb-2016-0160

© 2018 Her Majesty the Queen in right of Canada

Citation Information
Dema Najem, Kerry Rennie, Maria Ribecco-Lutkiewicz, Dao Ly, et al.. "Traumatic brain injury: classification, models, and markers." Biochemistry and Cell Biology / Biochimie et Biologie Cellulaire Vol. 96 Iss. 4 (2018) p. 391 - 406
Available at: http://works.bepress.com/douglas-fraser/41/