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Article
A therapeutic model for advanced endometrial cancer: systemic progestin in combination with local adenoviral-mediated progesterone receptor expression
Molecular cancer therapeutics
  • Donghai Dai, University of Iowa
  • L. Albitar
  • T. Nguyen
  • L. L. Laidler
  • M. Singh
  • K. K. Leslie
Document Type
Article
Peer Reviewed
1
Publication Date
1-1-2005
NLM Title Abbreviation
Mol Cancer Ther
PubMed ID
15657363
Abstract

Cancer of the uterine endometrium is a frequent gynecologic malignant disease for which few therapeutic options are available for advanced disease. Progesterone is the normal female hormone that limits growth and proliferation of endometrial cancers; however, progesterone receptors are frequently down-regulated, leading to treatment failures. The current studies explored the effectiveness of adenoviral-mediated progesterone receptor gene transduction in combination with progestin therapy in mouse xenograft models. Pretreatment of cells with progesterone receptor-encoding adenovirus and progestin inhibited the development of s.c. tumors in athymic mice. In the i.p. xenograft model, replacement of both isoforms of progesterone receptor, PRA and PRB, in combination with progestin treatment resulted in a significant 2.6-fold increase in overall survival time compared with control animals. These studies indicate that when progesterone receptor levels are maintained, progestin therapy is effective in limiting tumor growth. Future therapeutic regimens targeted at enhancing progesterone receptor expression have the potential to improve outcomes in women with endometrial cancer.

Keywords
  • Adenoviridae,
  • Animals,
  • Endometrial Neoplasms/drug therapy/pathology/therapy,
  • Female,
  • Genetic Vectors,
  • Humans,
  • Mice,
  • Mice,
  • Nude,
  • Peritoneal Neoplasms/pathology,
  • Progestins/therapeutic use,
  • Receptors,
  • Progesterone/genetics,
  • Transfection,
  • Transplantation,
  • Heterologous
Published Article/Book Citation
Molecular cancer therapeutics, 4:1 (2005) pp.169-175.
Disciplines
Citation Information
Donghai Dai, L. Albitar, T. Nguyen, L. L. Laidler, et al.. "A therapeutic model for advanced endometrial cancer: systemic progestin in combination with local adenoviral-mediated progesterone receptor expression" Molecular cancer therapeutics Vol. 4 Iss. 1 (2005) p. 169 - 175 ISSN: 1535-7163
Available at: http://works.bepress.com/donghai_dai/7/