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Article
The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer
Proceedings in Obstetrics and Gynecology
  • Xiangbing Meng, University of Iowa
  • Laura L. Laidler, University of New Mexico
  • Lina Albitar, University of New Mexico
  • Anna M. Holmes, University of New Mexico
  • Donghai Dai, University of Iowa
  • Thomas E. Buekers, University of Iowa
  • David P. Bender, University of Iowa
  • Kimberly K. Leslie, University of Iowa
Peer Reviewed
0
Publication Date
7-28-2011
Abstract

Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.

Keywords
  • Paclitaxel,
  • Gefitinib,
  • endometrial cancer,
  • mitotic catastrophe,
  • p38,
  • p53
Total Pages
2
Rights
Copyright © Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, Donghai Dai, Thomas E. Buekers, David P. Bender, Kimberly K. Leslie, 2011.
Creative Commons License
Creative Commons Attribution 3.0
Citation Information
Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, et al.. "The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer" (2011) p. 1 - 2 ISSN: 2154-4751
Available at: http://works.bepress.com/donghai_dai/1/