"(–)-Carbodine: Enantiomeric Synthesis and in Vitro Antiviral Activity Against Various Strains of Influenza Virus Including H5N1 (Avian Influenza) and Novel 2009 H1N1 (Swine Flu)" by J. R. Rao

Article

(–)-Carbodine: Enantiomeric Synthesis and in Vitro Antiviral Activity Against Various Strains of Influenza Virus Including H5N1 (Avian Influenza) and Novel 2009 H1N1 (Swine Flu)

Carbodine: enantiomeric synthesis and in vitro antiviral activity againstvarious strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1(swine flu)

J. R. Rao
A. K. Jha
R. K. Rawal
A. Sharon
C. W. Day
Dale L. Barnard, Utah State University
Donald F. Smee, Utah State University
C. K. Chu

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Document Type

Article

Publication Date

1-1-2010

Disciplines

Abstract

Enantiomerically pure cyclopentyl cytosine [(−)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (±)-carbodine and ribavirin. (−)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.

Comments

Bioorg. Med. Chem. Lett. 20:2601-2604. PMID: 20231094

Citation Information

Rao, J.R., Jha, A.K., Rawal, R.K., Sharon, A., Day, C.W., Barnard, D.L., Smee, D.F., Chu, C.K. 2010. (-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu). Bioorg. Med. Chem. Lett. 20:2601-2604. PMID: 20231094