Skip to main content
Article
Antifungal and insecticidal properties of the efrapeptins: Metabolites of the fungus Tolypocladium niveum
Journal of Invertebrate Pathology
  • S. B. Krasnoff
  • Sandeep Gupta
  • Raymond J. St. Leger
  • J. A. A. Renwick
  • Donald W. Roberts, Utah State University
Document Type
Article
Publication Date
9-1-1991
DOI
10.1016/0022-2011(91)90062-U
Disciplines
Abstract
Efrapeptins, peptides isolated from the fungus Tolypocladium niveum, showed toxic activity, as a crude mixture of five closely related compounds, against twospotted spider mite, Colorado potato beetle,southern armyworm, and tobacco budworm. The insecticidal activity of pure efrapeptins was characterized using two of the compounds against Colorado potado beetle in a foliar spray assay. Efrapeptin F (LC50 = 8.4 ppm) was about twice as potent as efrapeptin D (LC50 = 18.9 ppm). ATPase inhibitory activity of the efrapeptins was demonstrated using mitochondrial preparations from two fungal species, Metarhizium anisopliae and T. niveum, and from an insect, house fly. Against house fly mitochondria, efrapeptin D was the most potent ATPase inhibitor of five efrapeptins tested.
Citation Information
Krasnoff, S.B., S. Gupta, R.J. St. Leger, J.A.A. Renwick, and D.W. Roberts. 1991. Antifungal and insecticidal properties of the efrapeptins: Metabolites of the fungus Tolypocladium niveum. J. Invertebr. Pathol. 58: 180-188.