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About Don Oliver

We are using the simple, well-characterized, and genetically facile bacterium E. coli as a model system to study the molecular details of protein translocation across the plasma membrane. Our major focus is on SecA ATPase, a motor protein that binds preproteins and the translocon component SecYEG, and which undergoes ATP-driven conformational cycles at the membrane that promote the stepwise translocation of proteins across this membrane layer. Genetic, biochemical and biophysical approaches are being utilized along with our recent crystal structure of SecA protein in order to elucidate a number of important questions in this system.

Positions

Present Daniel Ayres Professor of Biology, Wesleyan University
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Disciplines