Skip to main content
ADAM function in embryogenesis
Seminars in Cell & Developmental Biology (2009)
  • Dominique Alfandari, University of Massachusetts - Amherst
  • C. McCusker
  • H. Cousin

Cleavage of proteins inserted into the plasma membrane (shedding) is an essential process controlling many biological functions including cell signaling, cell adhesion and migration as well as proliferation and differentiation. ADAM surface metalloproteases have been shown to play an essential role in these processes. Gene inactivation during embryonic development have provided evidence of the central role of ADAM proteins in nematodes, flies, frogs, birds and mammals. The relative contribution of four subfamilies of ADAM proteins to developmental processes is the focus of this review.

  • ADAM,
  • Disintegrin,
  • Metalloproteases,
  • Cell migration,
  • Cell adhesion,
  • Embryo
Publication Date
April, 2009
Publisher Statement
Citation Information
Dominique Alfandari, C. McCusker and H. Cousin. "ADAM function in embryogenesis" Seminars in Cell & Developmental Biology Vol. 20 Iss. 2 (2009)
Available at: