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Probing the State of Water on the Surface of Pharmaceutical Salts by X-ray Photoelectron Spectroscopy
Birck Poster Sessions
  • Pete Guerrieri, Industrial and Physical Pharmacy, Purdue University
  • Dmitry Zemlyanov, Birck Nanotechnology Center, Purdue University
  • Lynne S Taylor, Industrial and Physical Pharmacy, Purdue University
Comments
Poster for 2008 BNC Research Review
Abstract

•The results with both trifluoperazine di-HCl and clonidine HCl provide strong evidence for dissociative adsorption of water on organic hydrochloride salts. •This strongly bound water may act as nuclei for further moisture uptake and cause stability problems for moisture-labile salts. •Future work will investigate: • Role of surface chemistry and defect density of various faces of clonidine HCl single crystals on the extent of dissociation • Comparison between clonidine HCl, clonidine HBr and clonidine free base

Date of this Version
4-23-2008
Citation Information
Pete Guerrieri, Dmitry Zemlyanov and Lynne S Taylor. "Probing the State of Water on the Surface of Pharmaceutical Salts by X-ray Photoelectron Spectroscopy" (2008)
Available at: http://works.bepress.com/dmitry_zemlyanov/2/