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The construction of a Chinese MRI brain atlas: A morphometric comparison study between Chinese and Caucasian cohorts
NeuroImage (2010)
  • Ivo D Dinov, UCLA
Abstract

We developed a novel brain atlas template to facilitate computational brain studies of Chinese subjects and populations using high quality magnetic resonance imaging (MRI) and well-validated image analysis techniques. To explore the ethnicity-based structural brain differences, we used the MRI scans of 35 Chinese male subjects (24.03 ± 2.06 years) and compared them to an age-matched cohort of 35 Caucasian males (24.03 ± 2.06 years). Global volumetric measures were used to identify significant group differences in the brain length, width, height and AC–PC line distance. Using the LONI BrainParser, 56 brain structures were automatically labeled and analyzed for all subjects. We identified significant ethnicity differences in brain structure volumes, suggesting that a population-specific brain atlas may be more appropriate for studies involving Chinese populations. To address this, we constructed a 3D Chinese brain atlas based on high resolution 3.0T MRI scans of 56 right-handed male Chinese volunteers (24.46 ± 1.81 years). All Chinese brains were spatially normalized by using linear and nonlinear transformation via the “AIR Make Atlas” pipeline workflow within the LONI pipeline environment. This high-resolution Chinese brain atlas was compared to the ICBM152 template, which was constructed using Caucasian brains.

Publication Date
2010
Citation Information
Ivo D Dinov. "The construction of a Chinese MRI brain atlas: A morphometric comparison study between Chinese and Caucasian cohorts" NeuroImage (2010)
Available at: http://works.bepress.com/dinov/23/