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Copyright © 2017 Dimitrios Papandreou et al. Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (P <; 0.001). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (P < 0.001). Insulin resistance was significantly higher in children with NAFLD (P <; 0.001). Obese children presenting with MS were 3.01 (2.87-3.57, P < 0.002) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions: Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.
- glucose,
- high density lipoprotein,
- insulin,
- lipid,
- triacylglycerol,
- anthropometry,
- Article,
- body mass,
- cardiometabolic risk,
- child,
- disease association,
- disease course,
- echography,
- female,
- glucose blood level,
- hepatography,
- high risk patient,
- human,
- insulin blood level,
- insulin resistance,
- lipid blood level,
- major clinical study,
- male,
- metabolic syndrome X,
- nonalcoholic fatty liver,
- obesity,
- protein blood level,
- risk factor,
- school child,
- triacylglycerol blood level,
- waist circumference
Available at: http://works.bepress.com/dimitrios-papandreou/7/