Whether electromagnetic radiation (EMR) emitted from mobile phones is hazardous to human health is largely unknown. We investigated the effects of mobile phone radiation on critical organs in a rabbit model by exposing the animals to mobile phone radiation with sub-thermal specific absorption rate (SAR) of 1.0 and 0.7 W/kg for the head and the body, respectively, for 16 weeks (6 h/day, 6 days/week). There is no apparent change at the organ level. However, H&E staining showed that radiation-exposure significantly increased inflammatory cell infiltration in the liver and the lungs with a lesser degree of myocardial cell cytoplasmic vacuolation. In addition, results from γ-H2AX staining suggest that radiation can also cause DNA damage in the brain. Of note, no apparent activation of Caspase-3 in the organs examined. Our data altogether suggest that mobile phone radiation may be more hazardous to both the liver and the lungs, and less toxic to the brain and heart.