Article
MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis
iScience
Document Type
Article
Publication Date
12-20-2019
Disciplines
Abstract
Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3
PubMed ID
31810000
Citation Information
Liang Du, Lu Wang, Jinfeng Gan, Zhimeng Yao, et al.. "MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis" iScience Vol. 22 (2019) p. 353 - 368 Available at: http://works.bepress.com/dianzheng_zhang/95/
This article was published in iScience, Volume 22, pages 353-368.
The published version is available at https://doi.org/10.1016/j.isci.2019.11.009
Copyright © 2019 The Authors. CC BY-NC-ND 4.0