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The Oncogenic Roles of Nuclear Receptor Coactivator 1 in Human Esophageal Carcinoma
Cancer Medicine
  • Lu Wang
  • Weiwei Li
  • Kai Li
  • Yi Guo
  • Ditian Liu
  • Zhimeng Yao
  • Xianjie Lin
  • Shujun Li
  • Zuojie Jiang
  • Qing Liu
  • Yi Jiang
  • Beien Zhang
  • Lei Chen
  • Fuyou Zhou
  • Hongzheng Ren
  • Danxia Lin
  • Dianzheng Zhang, Philadelphia College of Osteopathic Medicine
  • Sai-Ching Jim Yeung
  • Hao Zhang
Document Type
Article
Publication Date
10-1-2018
Abstract

Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, dysregulations of NCOA1 have been found in a variety of cancer types. However, the clinical relevance and the functional roles of NCOA1 in human esophageal squamous cell carcinoma (ESCC) are less known. We found in this study that elevated levels of NCOA1 protein and/or mRNA as well as amplification of the NCOA1 gene occur in human ESCC. Elevated levels of NCOA1 due to these dysregulations were not only associated with more aggressive clinic-pathologic parameters but also poorer survival. Results from multiple cohorts of ESCC patients strongly suggest that the levels of NCOA1 could serve as an independent predictor of overall survival. In addition, silencing NCOA1 in ESCC cells remarkably decreased proliferation, migration, and invasion. These findings not only indicate that NCOA1 plays important roles in human ESCC but the levels of NCOA1 also could serve as a potential prognostic biomarker of ESCC and targeting NCOA1 could be an efficacious strategy in ESCC treatment.

Comments

This article was published in Cancer Medicine, Volume 7, Issue 10, pages 5205-5216.

The published version is available at https://dx.doi.org/10.1002%2Fcam4.1786.

Copyright © 2018 The Authors.

Citation Information
Lu Wang, Weiwei Li, Kai Li, Yi Guo, et al.. "The Oncogenic Roles of Nuclear Receptor Coactivator 1 in Human Esophageal Carcinoma" Cancer Medicine Vol. 7 Iss. 10 (2018) p. 5205 - 5216
Available at: http://works.bepress.com/dianzheng_zhang/67/