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MicroRNA-150 negatively regulates the function of CD4+ T cells through AKT3/Bim signaling pathway
Cellular immunology
  • Wei Sang
  • Cai Sun
  • Cong Zhang
  • Dianzheng Zhang, Philadelphia College of Osteopathic Medicine
  • Ying Wang
  • Linyan Xu
  • et al.
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Abstract Donor-derived CD4+ T lymphocytes are the major effector cells directly involved in the development of graft-versus-host disease (GVHD). As a negative regulator of immune cell differentiation and development, microRNA-150 (miR-150) induces immunological tolerance in CD4+ T cells after transplantation. However, the specific mechanisms have not been fully elucidated. In this study, we demonstrated that miR-150 is capable of not only inhibiting proliferation and activation of CD4+ T cells but also promoting apoptosis. Mechanistically, miR-150 targets v-akt murine thymoma viral oncogene homolog 3 (AKT3), and subsequently downregulates B-cell lymphoma 2 (Bcl-2) interacting mediator of cell death (BIM). We have also demonstrated that re-expression of AKT3 reversed miR-150-mediated inhibition of CD4+ T lymphocyte development. Therefore, we conclude that miR-150 negatively regulates CD4+ T cell function by inhibiting the AKT3/BIM signaling pathway. These findings also suggest that manipulating the levels of miRNA-150 could be a valuable strategy in prevention and/or treatment of acute graft-versus-host disease.


This article was published in Cellular immunology.

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Copyright © 2016 Elsevier .

Citation Information
Wei Sang, Cai Sun, Cong Zhang, Dianzheng Zhang, et al.. "MicroRNA-150 negatively regulates the function of CD4+ T cells through AKT3/Bim signaling pathway" Cellular immunology (2016)
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