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MicroRNA-181a, a potential diagnosis marker, alleviates acute graft versus host disease by regulating IFN-γ production.
American journal of hematology
  • Wei Sang
  • Cong Zhang
  • Dianzheng Zhang, Philadelphia College of Osteopathic Medicine
  • Ying Wang
  • Cai Sun
  • Mingshan Niu
  • Xiaoshen Sun
  • Cui Zhou
  • Lingyu Zeng
  • Bin Pan
  • Wei Chen
  • Dongmei Yan
  • Feng Zhu
  • Qingyun Wu
  • Jiang Cao
  • Kai Zhao
  • Chong Chen
  • Zhenyu Li
  • Depeng Li
  • Thomas P Loughran
  • Kailin Xu
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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a valuable therapeutic strategy for a wide variety of diseases. Acute graft-versus-host disease (aGVHD) is a major complication in up to 75% of allo-HSCT. The absence of a reliable predicative marker for aGVHD onset prevents preemptive treatment and impedes widespread and successful application of this therapy. In this study we found that after allo-HSCT, the levels of miR-181a were reduced significantly prior to the onset of aGVHD. More importantly, the degree of its reduction correlated with the severity of aGVHD. Mechanistically, miR-181a affects the function of T lymphocytes by down-regulating IFN-γ in a dose-dependent manner. Meanwhile, we confirmed that miR-181a can effectively preserve the anti-leukemic effect in vitro. Using a murine allo-HSCT model, we demonstrated that murine miR-181b, the human miR-181a homolog, served as an effective predictor of aGVHD. Moreover, expression of this microRNA ameliorated the severity of aGVHD. Collectively, these results show that the level of miR-181a may serve as a reliable marker for the diagnosis and prognosis the onset of aGVHD.

This article was published online as an accepted article for Hematology.

The published version is available at

Copyright © 2015 Wiley.

Citation Information
Wei Sang, Cong Zhang, Dianzheng Zhang, Ying Wang, et al.. "MicroRNA-181a, a potential diagnosis marker, alleviates acute graft versus host disease by regulating IFN-γ production." American journal of hematology (2015)
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