The Functions of ISG15 Ubiquitin-like Modifier and its Modifier EnzymesChinese Journal of Biochemistry and Molecular Biology
AbstractInterferon\|stimulated gene 15 encoded protein (ISG15) was identified as one of the first ubiquitin\|like modifier that induced by interferons. Numerous ISG15\|target proteins have been identified in tumors and virus\|infected cells. Multiple lines of evidence suggest that ISG15 plays important roles in the innate immune pathways and in cancer development. We focus on the structure and biochemical features of ISG15, as well as the mechanisms of the ISGylation of target proteins assisted with ISG15 modifier enzymes. The anti\|viral and anti\|cancer activities of ISG15 and its modifier enzymes are also discussed.
Citation InformationXinxing Wan, Dianzheng Zhang and Hanchun Chen. "The Functions of ISG15 Ubiquitin-like Modifier and its Modifier Enzymes" Chinese Journal of Biochemistry and Molecular Biology Vol. 26 Iss. 4 (2010) p. 295 - 300
Available at: http://works.bepress.com/dianzheng_zhang/28/