Objective: To investigate the inherited mutations and their association with clinical features and treatment response in young-onset prostate cancer patients.
Method: Targeted gene sequencing on 139 tumor susceptibility genes was conducted with a total of 24 patients diagnosed with PCa under the age of 63 years old. Meanwhile, the related clinical information of those patients is collected and analyzed.
Results: Sixty-two germline mutations in 45 genes were verified in 22 patients.
Conclusion: Mutations in DRGs are more prevalent in early-onset PCa with advanced clinical stages, and these patients had shorter progression-free survival. ADT Combined with either radiotherapy or chemotherapy may be effective in treating PCa caused by HRR-related gene mutations.
Available at: http://works.bepress.com/dianzheng_zhang/116/
This article was published in Frontiers in Oncology, Volume 12.
The published version is available at https://doi.org/10.3389/fonc.2022.826778.
Copyright © 2022 Tang, Tan, Wang, Wang, Wang, Xu, Wei, Zhang, Liu and Jiang. CC-BY 4.0.