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Article
Characterizing the Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides
Journal of Agricultural and Food Chemistry
  • Matthew L. Hillwig, Iowa State University
  • Kimberly D.P. Hammer, Iowa State University
  • Diane F. Birt, Iowa State University
  • Eve S. Wurtele, Iowa State University
Document Type
Article
Publication Date
1-1-2008
DOI
10.1021/jf800411v
Abstract
In this paper we characterize the metabolic fingerprint and first reported anti-inflammatory activity of Hypericum gentianoides. H. gentianoides has a history of medical use by Native Americans, but it has been studied very little for biological activity. High-performance liquid chromatography (HPLC) and liquid chromatography−electrospray ionization−mass spectrometry (LC-ESI-MS) analyses of a methanol extract show that H. gentianoides contains a family of over nine related compounds that have retention times, mass spectra, and a distinctive UV absorption spectra characteristic of certain acyl-phloroglucinols. These metabolites are abundant relative to other secondary products present in H. gentianoides, accounting for approximately 0.2 g per gram of dry plant tissue. H. gentianoides methanol extracts and a specific semipreparative HPLC fraction from these extracts containing the putative acyl-phloroglucinols reduce prostaglandin E2 synthesis in mammalian macrophages.
Comments

Posted with permission from Journal of Agricultural and Food Chemistry 56, no. 12 (2008): 4359–4366, doi:10.1021/jf800411v. Copyright 2008 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
Date Available
January 15, 2013
File Format
application/pdf
Citation Information
Matthew L. Hillwig, Kimberly D.P. Hammer, Diane F. Birt and Eve S. Wurtele. "Characterizing the Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides" Journal of Agricultural and Food Chemistry Vol. 56 Iss. 12 (2008) p. 4359 - 4366
Available at: http://works.bepress.com/diane_birt/7/