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Article
Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells
Journal of Agricultural and Food Chemistry
  • Kimberly D.P. Hammer, Iowa State University
  • Matthew L. Hillwig, Iowa State University
  • Avery K.S. Solco, Iowa State University
  • Philip M. Dixon, Iowa State University
  • Kathleen Delate, Iowa State University
  • Patricia A. Murphy, Iowa State University
  • Eve S. Wurtele, Iowa State University
  • Diane F. Birt, Iowa State University
Document Type
Article
Publication Date
1-1-2007
DOI
10.1021/jf0710074
Abstract
Hypericum perforatum (Hp) is commonly known for its antiviral, antidepressant, and cytotoxic properties, but traditionally Hp was also used to treat inflammation. In this study, the anti-inflammatory activity and cytotoxicity of different Hp extractions and accessions and constituents present within Hp extracts were characterized. In contrast to the antiviral activity of Hp, the anti-inflammatory activity observed with all Hp extracts was light-independent. When pure constituents were tested, the flavonoids, amentoflavone, hyperforin, and light-activated pseudohypericin, displayed anti-inflammatory activity, albeit at concentrations generally higher than the amount present in the Hp extracts. Constituents that were present in the Hp extracts at concentrations that inhibited the production of prostaglandin E2 (PGE2) were pseudohypericin and hyperforin, suggesting that they are the primary anti-inflammatory constituents along with the flavonoids, and perhaps the interactions of these constituents and other unidentified compounds are important for the anti-inflammatory activity of the Hp extracts.
Comments

Posted with permission from Journal of Agricultural and Food Chemistry 55, no. 18 (2007): 7323–7331, doi:10.1021/jf0710074. Copyright 2007 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Kimberly D.P. Hammer, Matthew L. Hillwig, Avery K.S. Solco, Philip M. Dixon, et al.. "Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells" Journal of Agricultural and Food Chemistry Vol. 55 Iss. 18 (2007) p. 7323 - 7331
Available at: http://works.bepress.com/diane_birt/2/