The effect of i.v. acepromazine (0.05 mg/kg bwt), butorphanol (0.05 mg/kg bwt) and a combination of acepromazine and butorphanol on halothane minimum alveolar concentration (MAC) was determined in 7 mixed-breed ponies. Ventilation was controlled, and blood pressure and temperature were maintained within normal limits. Following the determination of baseline MAC, treatments were administered to each pony in a random manner. The control treatment was normal saline. The baseline halothane MAC for the control group was 0.910.04%, and no significant change occurred after saline administration. Acepromazine decreased the halothane MAC from 0.920.02% to 0.580.04%, and the combination of acepromazine and butorphanol, decreased halothane MAC 0.950.04% to 0.590.06%, a decrease of 36.9 and 37.8%, respectively. The difference between these 2 treatments was not significant. Butorphanol did not significantly change the mean group value for MAC.
- acepromazine anaesthesia butorphanol halothane neuroleptics pharmacology preanaesthetic medication horses acetylpromazine anesthesia preanesthetic medication Equus Equidae Perissodactyla mammals vertebrates Chordata animals ungulates eukaryotes
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