The effects of epidurally administered xylazine on halothane minimum alveolar concentration (MAC) were examined in 6 healthy pony geldings. Anaesthesia was induced with i.v. administration of thiopentone (4 mg/kg) and succinylcholine (0.15 mg/kg) and maintained with halothane in oxygen. Following baseline halothane MAC determination, each pony was given 0.15 mg/kg xylazine hydrochloride or saline epidurally. No change in halothane MAC was observed following saline administration. Xylazine administration, however, significantly decreased halothane MAC from 0.93 to 0.61% in the thoracic limb and from 0.93 to 0.53% in the pelvic limb. Recovery from anaesthesia was uneventful and no adverse effect was observed. It is concluded that epidural xylazine has significant antinociceptive effect in ponies.
- anaesthesia anaesthetics conduction anaesthesia drug combinations halothane xylazine horses anesthesia anesthetics conduction anesthesia epidural anaesthesia Equus Equidae Perissodactyla mammals vertebrates Chordata animals ungulates eukaryotes
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