Total protein (TP), albumin, and IgG concentrations were measured in CSF from the atlanto-occipital (AO) and lumbosacral (LS) sites and in serum of 15 clinically normal neonatal foals 10 days old (mean 7 days). The albumin quotient (AQ; CSF albumin/serum albumin * 100) and IgG index ([CSF IgG/serum IgG] * [serum albumin/CSF albumin]), indicators of blood-brain barrier permeability and intrathecal IgG production, respectively, were then calculated. Mean SD values were: serum albumin, 2900 240 mg/dl; serum IgG, 1325 686 mg/dl; AO CSF TP, 82.8 19.2 mg/dl; LS CSF TP, 83.6 16.1 mg/dl; AO CSF albumin, 52 8.6 mg/dl; LS CSF albumin, 53.8 15.7 mg/dl; AO CSF IgG, 10.2 5.5 mg/dl; LS CSF IgG 9.9 5.7 mg/dl; AO AQ, 1/86 0.29; LS AQ, 1.85 0.51, AO IgG index, 0.52 0.28; and LS IgG index, 0.48 0.27. No significant difference between values for AO and LS sites was found. It was concluded a CSF albumin concentration >85.2 mg/dl or AQ >2.4, as determined by mean 2 SD, may indicate increased blood-brain barrier permeability. An IgG index value >1.0 may indicate intrathecal IgG production. Values obtained for foals of this study should serve as baseline for comparison in the evaluation of blood-brain barrier permeability and intrathecal IgG production in neonatal foals with neurological disease.
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