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Article
Albumin quotient, IgG concentration, and IgG index determinations in cerebrospinal fluid of neonatal foals
American Journal of Veterinary Research (1994)
  • F.M. Andrews
  • Dennis R. Geiser, DVM, University of Tennessee - Knoxville
  • C.S. Sommardahl
  • E.M. Green
  • M. Provenza
Abstract

Total protein (TP), albumin, and IgG concentrations were measured in CSF from the atlanto-occipital (AO) and lumbosacral (LS) sites and in serum of 15 clinically normal neonatal foals 10 days old (mean 7 days). The albumin quotient (AQ; CSF albumin/serum albumin * 100) and IgG index ([CSF IgG/serum IgG] * [serum albumin/CSF albumin]), indicators of blood-brain barrier permeability and intrathecal IgG production, respectively, were then calculated. Mean SD values were: serum albumin, 2900 240 mg/dl; serum IgG, 1325 686 mg/dl; AO CSF TP, 82.8 19.2 mg/dl; LS CSF TP, 83.6 16.1 mg/dl; AO CSF albumin, 52 8.6 mg/dl; LS CSF albumin, 53.8 15.7 mg/dl; AO CSF IgG, 10.2 5.5 mg/dl; LS CSF IgG 9.9 5.7 mg/dl; AO AQ, 1/86 0.29; LS AQ, 1.85 0.51, AO IgG index, 0.52 0.28; and LS IgG index, 0.48 0.27. No significant difference between values for AO and LS sites was found. It was concluded a CSF albumin concentration >85.2 mg/dl or AQ >2.4, as determined by mean 2 SD, may indicate increased blood-brain barrier permeability. An IgG index value >1.0 may indicate intrathecal IgG production. Values obtained for foals of this study should serve as baseline for comparison in the evaluation of blood-brain barrier permeability and intrathecal IgG production in neonatal foals with neurological disease.

Publication Date
1994
Citation Information
F.M. Andrews, Dennis R. Geiser, C.S. Sommardahl, E.M. Green, et al.. "Albumin quotient, IgG concentration, and IgG index determinations in cerebrospinal fluid of neonatal foals" American Journal of Veterinary Research Vol. 55 Iss. 6 (1994)
Available at: http://works.bepress.com/dennis_geiser/15/