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Article
Unusually Indolent T-Cell Prolymphocytic Leukemia Associated with a Complex Karyotype: Is This T-Cell Chronic Lymphocytic Leukemia?
American journal of hematology
  • Lorinda Soma
  • Dennis B Cornfield, MD, Lehigh Valley Health Network
  • David Prager
  • Peter Nowell
  • Adam Bagg
Publication/Presentation Date
11-1-2002
Abstract
T-cell prolymphocytic leukemia (T-PLL) is typically associated with an aggressive clinical course, with a median survival of less than 1 year. We report a case of T-PLL that displays multiple cytogenetic abnormalities, with the most complex subclone having the following karyotype: 47, Y, -X, +8, inv (10) (p12q26), del (11) (p13p15) +marker. However, despite this genetic complexity, the leukemia has behaved in a remarkably indolent manner, with the patient remaining asymptomatic, without therapeutic intervention, for more than 7 years. The unusually benign behavior of this disease calls into question the validity of grouping such cases under the umbrella of T-PLL and warrants a reconsideration of T-cell chronic lymphocytic leukemia (no longer recognized as a distinct disease) as a bona fide diagnostic entity.
Disciplines
PubMedID
12410582
Document Type
Article
Citation Information

Soma, L., Cornfield, D. B., Prager, D., Nowell, P., & Bagg, A. (2002). Unusually indolent T-cell prolymphocytic leukemia associated with a complex karyotype: is this T-cell chronic lymphocytic leukemia?. American Journal Of Hematology, 71(3), 224-226.