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Article
Fluorescent Dye Encapsulated ZnO Particles with Cell-Specific Toxicity for Potential Use in Biomedical Applications
Journal of Materials Science: Materials in Medicine
  • Hua Wang, Boise State University
  • Denise G. Wingett, Boise State University
  • Mark H. Engelhard, Pacific Northwest National Laboratory
  • Kevin P. Feris, Boise State University
  • K. M. Reddy, Boise State University
  • Paul Turner, Boise State University
  • Janet Layne, Boise State University
  • Cory Hanley, Boise State University
  • Jason Bell, Boise State University
  • Dmitri Tenne, Boise State University
  • Chongmin Wang, Pacific Northwest National Laboratory
  • Alex Punnoose, Boise State University
Document Type
Article
Publication Date
1-1-2009
DOI
http://dx.doi.org/10.1007/s10856-008-3541-z
Disciplines
Abstract

Fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer have been synthesized for the first time as multifunctional "smart" nanostructures. Detailed characterization studies confirmed the formation of an outer ZnO layer on the SiO2–FITC core. These ~200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/ml) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≥250–500 μg/ml (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the novel FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.

Citation Information
Hua Wang, Denise G. Wingett, Mark H. Engelhard, Kevin P. Feris, et al.. "Fluorescent Dye Encapsulated ZnO Particles with Cell-Specific Toxicity for Potential Use in Biomedical Applications" Journal of Materials Science: Materials in Medicine (2009)
Available at: http://works.bepress.com/denise_wingett/12/