Article
No TNF-κB controls growth of glioblastomas/astrocytomastle
Molecular and Cellular Biochemistry volume
(2008)
Abstract
NF-κB is a family of transcription factors that have been shown to be elevated in a variety of tumor types and in some cases central to their survival and growth. Here we present evidence that U-87 MG and U-118 MG growth is regulated by NF-κB and controlled by PDGF. NF-κB activity was suppressed by a dominant negative mutant of the human PDGF type β receptor and PDGF-B chain neutralizing antibodies. Creation of cell lines that had inducible expression of shRNAs directed against either c-Rel or RelA inhibited growth almost 90% indicating that NF-κB plays a central role in glioblastoma growth.
Disciplines
Publication Date
2008
Citation Information
Denise Smith. "No TNF-κB controls growth of glioblastomas/astrocytomastle" Molecular and Cellular Biochemistry volume Vol. 307 (2008) p. 141 - 147 Available at: http://works.bepress.com/denise_smith/17/