|Present||Associate Professor of Pharmaceutical Sciences, Cedarville University ‐ School of Pharmacy|
Honors and Awards
- American Association of Colleges of Pharmacy New Investigator Award - 2015
- International Narcotics Research Conference Young Investigators Travel Award - 2008
- International Narcotics Research Conference Young Investigators Travel Award - 2007
- American Society of Pharmacognosy Active Members Travel Award - 2006
- West Indies Group of University Teachers Award - 1999
- University of the West Indies Chemical Society of Alumni and Friends Award - 1998
- Southwestern Ohio Council for Higher Education Faculty Excellence in Teaching Award - 2017
- Pharmaceutical Sciences I & II
- Pharmacognosy and Herbal Medicines
- Infectious Disease & Immunology
- Oncology & Palliative Care
|B.Sc. in Chemistry and Food Chemistry, University of the West Indies, Mona, Jamaica|
|Ph.D. in Chemistry, University of the West Indies, Mona, Jamaica|
School of Pharmacy
Refereed Journal Articles (21)
Evaluation of the Anticancer Activity of Bioactive Fraction G Extracted from Pavetta crassipes in Malignant Brain Tumor Cell Lines American Journal of Phytomedicine and Clinical Therapeutics (2017)
Objective: Natural products have served as sources of lead compounds that are commonly used in the treatment of human diseases including cancer. Pavetta crassipes has been widely demonstrated to have ethnopharmacological potential in the management ...
The Antiproliferative and Apoptotic Effects of Apigenin on Glioblastoma Cells The Journal of Pharmacy and Pharmacology (2017)
OBJECTIVES: Glioblastoma (GBM) is highly proliferative, infiltrative, malignant and the most deadly form of brain tumour. The epidermal growth factor receptor (EGFR) is overexpressed, amplified and mutated in GBM and has been shown to play ...
Pharmacology and Anti-Addiction Effects of the Novel κ Opioid Receptor Agonist Mesyl Sal B, a Potent and Long-Acting Analogue of Salvinorin A British Journal of Pharmacology (2015)
Background and Purpose: Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia ...
Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity Journal of Medicinal Chemistry (2014)
A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability ...
Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication ACS Chemical Biology (2014)
The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is both a protease, which cleaves viral and host proteins, and a helicase that separates nucleic acid strands, using ATP hydrolysis to fuel the reaction. Many ...
Potent and Selective Inhibitors of the TASK-1 Potassium Channel Through Chemical Optimization of a Bis-amide Scaffold Bioorganic & Medicinal Chemistry Letters (2014)
TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better ...
Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe The Journal of Biological Chemistry (2013)
Cdc42 plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. Overactive Cdc42 has been implicated in the pathology of cancers, immune diseases, and neuronal disorders. Therefore, Cdc42 inhibitors would be ...
A Selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor Revealed via High-Throughput Flow Cytometry Journal of Biomolecular Screening (2013)
Chemotherapeutics tumor resistance is a principal reason for treatment failure, and clinical and experimental data indicate that multidrug transporters such as ATP-binding cassette (ABC) B1 and ABCG2 play a leading role by preventing cytotoxic intracellular ...
A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition ACS Chemical Biology (2012)
Mapping the functionality of GTPases through small molecule inhibitors represents an underexplored area in large part due to the lack of suitable compounds. Here we report on the small chemical molecule 2-(benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid (PubChem CID ...
Antinociceptive Effects of Herkinorin, a MOP Receptor Agonist Derived from Salvinorin A in the Formalin Test in Rats: New Concepts in Mu Opioid Receptor Pharmacology: From a Symposium on New Concepts in Mu-Opioid Pharmacology Drug and Alcohol Dependence (2012)
Herkinorin is the first μ opioid (MOP) selective agonist derived from salvinorin A, a hallucinogenic natural product. Previous work has shown that, unlike other opioids, herkinorin does not promote the recruitment of β-arrestin-2 to the ...
Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A MedChemComm (Medicinal Chemistry Communications) (2011)
Previous structure-activity relationship studies of salvinorin A have shown that modification of the acetate functionality off the C-2 position to a methoxy methyl or methoxy ethyl ether moiety leads to increased potency at KOP receptors. ...
Tetranortriterpenoids from Spathelia Sorbifolia (Rutaceae) Natural Product Communications (2010)
Two new tetranortriterpenoids were obtained by chromatography of the acetone extract of the wood of Spathelia sorbifolia L.; these compounds were characterized as their p-bromobenzoyl derivatives (2, 3). This extract also yielded a known tetranortriterpenoid ...
Synthetic Studies of Neoclerodane Diterpenes from Salvia Divinorum: Role of the Furan in Affinity for Opioid Receptors Organic & Biomolecular Chemistry (2009)
Further synthetic modification of the furan ring of salvinorin A (1), the major active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. A computational study has predicted ...
Utilizing Nature as a Source of New Probes for Opioid Pharmacology Future Medicinal Chemistry (2009)
Background: Traditional and current opioid pharmacology is fundamentally based on interactions between opioid receptors and compounds isolated from natural sources. Adverse effects associated with opioids have led to the search for compounds with diminished side ...
The Effects of Herkinorin, the First mu-Selective Ligand from a Salvinorin A-Derived Scaffold, in a Neuroendocrine Biomarker Assay in Nonhuman Primates Journal of Pharmacology and Experimental Therapeutics (2008)
Herkinorin is the first μ-opioid receptor-selective ligand from the salvinorin A diterpenoid scaffold. Herkinorin has relative μ > κ > δ binding selectivity, and it can act as an agonist at both μ- and κ-receptors, ...
Differential Effects of Opioid Agonists on G-Protein Expression in CHO Cells Expressing the Cloned Human Opioid Receptors Brain Research Bulletin (2008)
Recent evidence indicates that agonist ligands of G protein coupled receptors (GPCR) can activate different signaling systems. Such “agonist-directed” signaling also occurs with opioid receptors. Previous work from our laboratory showed that chronic morphine, but ...
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Preparation and Opioid Receptor Activity of Salvinicin Analogues Journal of Medicinal Chemistry (2007)
Further modification of salvinorin A (1a), the major active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study that oxadiazole ...
Research Reports (7)
A Small Molecule Pan-Inhibitor of Ras-Superfamily GTPases with High Efficacy Towards Rab7 Pharmaceutical Sciences Faculty Publications (2013)
Low molecular weight guanine triphosphate hydrolases (GTPases) are GTP-binding enzymes that play pivotal roles in cell biology. Grouped into three subfamilies which are designated by function, Ras, Rho and Rab GTPases are involved in signal ...
Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9 Pharmaceutical Sciences Faculty Publications (2013)
ML308 was identified as a novel inhibitor of the potassium channel, subfamily K, member 9 (KCNK9) two-pore domain potassium channel. Two-pore domain potassium channels provide a background leak conductance that is selectively permeable to potassium. ...
Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization Pharmaceutical Sciences Faculty Publications (2013)
Respiratory Syncytial Virus (RSV) is the most common cause of bronchiolitis and pneumonia among infants under one year of age. Most children will be infected with RSV prior to their second birthday, leading to 75,000-125,000 ...