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Endometritis in postparturient cattle associated with bovine herpesvirus-4 infection: 15 cases.
Journal of Veterinary Diagnostic Investigation (2001)
  • K. Frazier
  • M. Pence
  • M. J. Mauel
  • A. Liggett
  • M. E. Hines II
  • L. Sangster
  • H. D. Lehmkuhl
  • Debra L Miller, University of Tennessee, Knoxville
  • E. Styer
  • J. West
  • C. A. Baldwin
Suppurative, ulcerative endometritis associated with bovine herpesvirus-4 (BHV-4) infection was identified in 15 postparturient dairy cows from 5 separate dairies. Characteristic eosinophilic to amphophilic intranuclear viral inclusion bodies were identified within degenerate endometrial lining epithelium and endothelial cells. Bovine herpesvirus-4 was confirmed as the etiology by a combination of fluorescent antibody assays, viral isolation, heminested PCR, ultrastructural examination of the uterus and inoculated tissue culture cells, and negative-stain electron microscopy of tissue culture supernatant. Viral particles measuring 70-95 nm were demonstrated in uterine epithelial and endothelial cells by electron microscopy. Bacteria including Arcanobacterium pyogenes, Escherichia coli, and an alpha-Streptococcus isolate were isolated from all uteri. Bovine herpesvirus-4-associated endometritis has been previously reported in sporadic cases in Europe but has not been previously reported in the United States. Endometritis associated with BHV-4 appears to be an emerging syndrome in Georgia dairy herds.
Publication Date
Citation Information
K. Frazier, M. Pence, M. J. Mauel, A. Liggett, et al.. "Endometritis in postparturient cattle associated with bovine herpesvirus-4 infection: 15 cases." Journal of Veterinary Diagnostic Investigation Vol. 13 Iss. 6 (2001)
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