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Signs of Mood and Anxiety Disorders in Chimpanzees
  • Hope Ferdowsian, George Washington University
  • Debra Durham, Physicians Committee for Responsible Medicine
  • Charles Kimwele, University of Nairobi
  • Godelieve Kranendonk, AAP Sanctuary for Exotic Animals
  • Emily Otali, Makerere University
  • Timothy Akugizibwe, Wildlife Conservation Society
  • J. B. Mulcahy, Chimpanzee Sanctuary Northwest
  • Lilly Ajarova, Chimpanzee Sanctuary and Wildlife Conservation Trust
  • Cassie Meré Johnson, Physicians Committee for Responsible Medicine
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Background: In humans, traumatic experiences are sometimes followed by psychiatric disorders. In chimpanzees, studies have demonstrated an association between traumatic events and the emergence of behavioral disturbances resembling posttraumatic stress disorder (PTSD) and depression. We addressed the following central question: Do chimpanzees develop posttraumatic symptoms, in the form of abnormal behaviors, which cluster into syndromes similar to those described in human mood and anxiety disorders? Methodology/Principal Findings: In phase 1 of this study, we accessed case reports of chimpanzees who had been reportedly subjected to traumatic events, such as maternal separation, social isolation, experimentation, or similar experiences. We applied and tested DSM-IV criteria for PTSD and major depression to published case reports of 20 chimpanzees identified through PrimateLit. Additionally, using the DSM-IV criteria and ethograms as guides, we developed behaviorally anchored alternative criteria that were applied to the case reports. A small number of chimpanzees in the case studies met DSM-IV criteria for PTSD and depression. Measures of inter-rater reliability, including Fleiss’ kappa and percentage agreement, were higher with use of the alternative criteria for PTSD and depression. In phase 2, the alternative criteria were applied to chimpanzees living in wild sites in Africa (n = 196) and chimpanzees living in sanctuaries with prior histories of experimentation, orphanage, illegal seizure, or violent human conflict (n = 168). In phase 2, 58% of chimpanzees living in sanctuaries met the set of alternative criteria for depression, compared with 3% of chimpanzees in the wild (p = 0.04), and 44% of chimpanzees in sanctuaries met the set of alternative criteria for PTSD, compared with 0.5% of chimpanzees in the wild (p = 0.04). Conclusions/Significance: Chimpanzees display behavioral clusters similar to PTSD and depression in their key diagnostic criteria, underscoring the importance of ethical considerations regarding the use of chimpanzees in experimentation and other captive settings.
Citation Information
Ferdowsian HR, Durham DL, Kimwele C, Kranendonk G, Otali E, et al. (2011) Signs of Mood and Anxiety Disorders in Chimpanzees. PLoS ONE 6(6): e19855. doi:10.1371/journal.pone.0019855