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Article
The Effect of Fluoride Treatment on Bone Mineral in Rabbits
1990-1999
  • Debbie Chachra, Franklin W. Olin College of Engineering
  • C. H. Turner, Indiana University Schools of Medicine and Dentistry
  • A. J. Dunipace, Indiana University Schools of Medicine and Dentistry
  • Marc D. Grynpas, Samuel Lunenfeld Research Institute
Document Type
Article
Publication Date
1-1-1999
Abstract
Fluoride therapy has been used clinically for many years, but its use remains controversial and many basic questions remain unanswered. Accordingly, this study returns to an animal model to study the effects of high doses of fluoride on bone mineral in rabbits. Twelve rabbits, aged 3½ months at the start of the study, received drinking water fluoridated at 100 ppm while their 12 control counterparts drank distilled water. All rabbits were sacrificed after 6 months. Fluoride was readily incorporated into femoral cortical bone (7473 ± 966 ppm F versus 1228 ± 57 ppm in controls; P < 0.00005). Fluoride therapy led to increased mineralization, as measured by density fractionation (P < 0.0005 for the distributions). The bone mineral itself was altered, with a significant increase in the width of crystals (66.2 ± 2.0 Å versus 61.2 ± 0.9 Å; P < 0.01). The microhardness of both cortical and cancellous bone in the femoral head of fluoride-treated rabbits was greater than that in the controls (P < 0.05). The phosphate, calcium, and carbonate contents in the bone was the same in both groups. Finally, fluoride administration did not affect the architecture or connectivity of cancellous bone in the femoral head. Previously published data [1] indicated that the mechanical properties of bone were adversely affected; this suggests that the effect of high doses of fluoride on the strength and stiffness of bone may be mediated by its effect on bone mineral.
Comments

© 1999 Springer Verlag. This article was published in Calcified Tissue International, vol.64, iss. 4, pp. 345-351 and may be found here.

Citation Information
Debbie Chachra, C. H. Turner, A. J. Dunipace and Marc D. Grynpas. "The Effect of Fluoride Treatment on Bone Mineral in Rabbits" (1999)
Available at: http://works.bepress.com/debbie_chachra/9/