Demand for assessment and treatment of dementia patients and their families is expected to increase substantially by the end of this decade, considering current estimates of about 4 million dementia patients. This article guides social work practice in the assessment of dementia patients and their families using an ecological-family-centered (EFC) model of practice. A case presentation illustrates how to apply the ECF model while incorporating ethnically sensitive practice principles. The model organizes complex assessment issues that often arise when working with families of dementia patients and illustrates the significance of cultural diversity in case practice. Literature on families of dementia patients is reviewed, an intervention plan for the family system is outlined, and implications for practice are noted.