This Masterclass will describe why and how a medical school transitioned to a lecture-free curriculum. The presenters will update participants on the latest findings from cognitive neuroscience and psychology on how we learn best, with a focus on the learning of science. Next, they will demonstrate, with participant engagement, two evidence-based instructional strategies that were adopted and adapted to one school’s context – making it possible to eliminate lectures. With participant engagement, the barriers and enablers inherent in a major curricular transformation will be addressed to empower participants to work for change at their home institutions.