IEEE 1599 is an international standard originally conceived for music, which aims at providing a comprehensive description of the media contents related to a music piece within a multi-layer and synchronized environment. A number of o_- line and stand-alone software prototypes has been realized after its standardization, occurred in 2008. Recently, thanks to some technological advances (e.g. the release of HTML5), the engine of the IEEE 1599 parser has been ported on the Web. Some non-trivial problems have been solved, e.g. the management of multiple simultaneous media streams in a client-server architecture. After providing an overview of the IEEE 1599 standard, this article presents a survey of the recent initiatives regarding audio-driven synchronization over the Web.