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Article
Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses
Advances in Microbiology
  • Megan Ottomeyer
  • Ali Mohammadkah
  • D. E. Day, Missouri University of Science and Technology
  • David J. Westenberg, Missouri University of Science and Technology
Abstract

Bioactive glasses have been developed for medical applications in the body for bone and tissue repair and regeneration. We have developed a borate-containing bioactive glass (13-93B3, referred to as B3), which is undergoing clinical trials to assess its wound-healing properties. To complement the healing properties of B3, metal ion dopants have been added to enhance its antimicrobial properties. Bioactive glasses doped with silver, gallium or iodine ions were found to have broad spectrum antimicrobial effects on clinically relevant bacteria including MRSA. While the B3 glass alone was sufficient to produce antibacterial effects on select bacteria, adding dopants enhanced the broad-spectrum antibacterial properties: Live-Dead staining fluorescence microscopy suggests cell membrane integrity is disrupted in gram positive bacteria exposed to the glass compounds, but not gram negative bacteria, indicating multiple mechanisms of action for each glass formulation.

Department(s)
Materials Science and Engineering
Second Department
Biological Sciences
Keywords and Phrases
  • Bioactive Glass,
  • Antibacterial Properties,
  • Metal Ions
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2016 Scientific Research, All rights reserved.
Creative Commons Licensing
Creative Commons Attribution 4.0
Publication Date
9-1-2016
Disciplines
Citation Information
Megan Ottomeyer, Ali Mohammadkah, D. E. Day and David J. Westenberg. "Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses" Advances in Microbiology Vol. 6 Iss. 10 (2016) p. 776 - 787 ISSN: 2165-3410;2165-3402
Available at: http://works.bepress.com/david_westenberg/20/