To introduce this special issue, the guest editors present an overview of the articles within the context of an introduction to science and technology studies (STS). STS scholarship addresses social, historical, and philosophical issues concerning the practices of science and technology, and the articles illustrate the emergence of STS ideas in the fields of educational technology and science education. The editors discuss different approaches within STS and situate the entire field within post-Enlightenment modernity. The representation of scientific and technological knowledge is a central concern in STS, and the editors critically examine efforts to fix the meaning of such knowledge.