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Article
Assembly of Motor Circuits in the Spinal Cord: Driven to Function by Genetic and Experience-Dependent Mechanisms
Neuron
  • David R. Ladle, Wright State University - Main Campus
  • Eline Pecho-Vrieseling
  • Silvia Arber
Document Type
Article
Publication Date
10-25-2007
Abstract
Motor circuits in the spinal cord integrate information from various sensory and descending pathways to control appropriate motor behavior. Recent work has revealed that target-derived retrograde signaling mechanisms act to influence sequential assembly of motor circuits through combinatorial action of genetic and experience-driven programs. These parallel activities imprint somatotopic information at the level of the spinal cord in precisely interconnected circuits and equip animals with motor circuits capable of reacting to changing demands throughout life.
DOI
10.1016/j.neuron.2007.09.026
Citation Information
David R. Ladle, Eline Pecho-Vrieseling and Silvia Arber. "Assembly of Motor Circuits in the Spinal Cord: Driven to Function by Genetic and Experience-Dependent Mechanisms" Neuron Vol. 56 Iss. 2 (2007) p. 270 - 283 ISSN: 0896-6273
Available at: http://works.bepress.com/david_ladle/7/