RNA processing and exportBiochemistry and Molecular Pharmacology Publications and Presentations
UMMS AffiliationDepartment of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
Medical Subject HeadingsActive Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic
AbstractMessenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
Related ResourcesLink to Article in PubMed
Citation InformationSami Hocine, Robert H. Singer and David Grunwald. "RNA processing and export" Vol. 2 Iss. 12 (2010) ISSN: 1943-0264 (Electronic)
Available at: http://works.bepress.com/david_grunwald/16/