RNA processing and exportBiochemistry and Molecular Pharmacology Publications and Presentations
UMMS AffiliationDepartment of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
SubjectsActive Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic
AbstractMessenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
DOI of Published Version10.1101/cshperspect.a000752
Hocine S, Singer RH, Grünwald D. RNA processing and export. Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000752. doi:10.1101/cshperspect.a000752.
Related ResourcesLink to Article in PubMed
Citation InformationSami Hocine, Robert H. Singer and David Grunwald. "RNA processing and export" Vol. 2 Iss. 12 (2010) ISSN: 1943-0264 (Electronic)
Available at: http://works.bepress.com/david_grunwald/16/