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Article
RNA processing and export
Biochemistry and Molecular Pharmacology Publications and Presentations
  • Sami Hocine, Albert Einstein College of Medicine
  • Robert H. Singer, Albert Einstein College of Medicine
  • David Grunwald, University of Massachusetts Medical School
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
Date
12-1-2010
Document Type
Article
Medical Subject Headings
Active Transport, Cell Nucleus; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic
Abstract
Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
Comments

Citation: Hocine S, Singer RH, Grünwald D. RNA processing and export. Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000752. doi:10.1101/cshperspect.a000752.

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
20961978
Update Submission
Revision
Citation Information
Sami Hocine, Robert H. Singer and David Grunwald. "RNA processing and export" Vol. 2 Iss. 12 (2010) ISSN: 1943-0264 (Electronic)
Available at: http://works.bepress.com/david_grunwald/16/