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Article
Nuclear export dynamics of RNA-protein complexes
Biochemistry and Molecular Pharmacology Publications and Presentations
  • David Grunwald, University of Massachusetts Medical School
  • Robert H. Singer, Albert Einstein College of Medicine
  • Michael Rout, Rockefeller University
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology; RNA Therapeutics Institute
Publication Date
7-20-2011
Document Type
Article
Subjects
Active Transport, Cell Nucleus; Cell Nucleus; Cytoplasm; Humans; Microscopy; Nuclear Pore; RNA; Ribonucleoproteins; Ribosomes
Abstract

The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

DOI of Published Version
10.1038/nature10318
Source

Grünwald D, Singer RH, Rout M. Nuclear export dynamics of RNA-protein complexes. Nature. 2011 Jul 20;475(7356):333-41. doi: 10.1038/nature10318. Link to article on publisher's site

Comments

At the time of publication, David Grünwald was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
21776079
Citation Information
David Grunwald, Robert H. Singer and Michael Rout. "Nuclear export dynamics of RNA-protein complexes" Vol. 475 Iss. 7356 (2011) ISSN: 0028-0836 (Linking)
Available at: http://works.bepress.com/david_grunwald/15/