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Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems
Pharmaceutics
  • Mozhgan Aghajanzadeh, University of Guilan
  • Mostafa Zamani, University of Guilan
  • Fereshteh Rajabi Kouchi, Boise State University
  • Josh Eixenberger, Boise State University
  • Dorsa Shirini, Shahid Beheshti University of Medical Sciences
  • David Estrada, Boise State University
  • Farhad Shirini, University of Guilan
Document Type
Article
Publication Date
2-1-2022
Abstract

This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

Comments

Mozhgan Aghajanzadeh, Mostafa Zamani, and Fereshteh Rajabi Kouchi contributed equally to this work.

Creative Commons License
Creative Commons Attribution 4.0 International
Citation Information
Mozhgan Aghajanzadeh, Mostafa Zamani, Fereshteh Rajabi Kouchi, Josh Eixenberger, et al.. "Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems" Pharmaceutics (2022)
Available at: http://works.bepress.com/david_estrada/85/