The exponential increase in herbicide resistant weeds around the globe poses a “wicked problem” that resists solutions developed from disciplinary science (Ervin and Jussaume; Shaw). Traditonal voluntary education and technical assistance approaches have failed to stem the advance of resistance. Scholars and practitioners recognize that improved understanding of human behavior leading to more resistant weeds must provide the foundation of knowledge for innovating more effective approaches. Principles to negotiate progress on wicked problems stress interdisciplinary approaches that integrate frontier social and natural science concepts with stakeholder experiences to discover novel approaches (Sayer et al). Standard templates to address the problem in varying biophysical and socioeconomic settings will not capture the heterogeneity of production agriculture conditions across countries. This session presents papers on innovating constructive approaches to herbicide resistance through improved understanding of human behavior. Leading scientists and practitioners present their experiences with interdisciplinary approaches to uncover key human behaviors that drive farmer decision making related to herbicide resistant weeds. The papers emphasize the integration of experiential and scientific knowledge bases by stakeholders informing science and practice. Accomplishing this integration is necessary to innovate more effective public and private approaches for managing herbicide resistance that jeopardizes progress on advancing the bioeconomy.