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Article
Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
Cancer letters
  • N. J. Nadkarni
  • Koen De Geest, University of Iowa
  • T. Neff
  • B. D. Young
  • D. P. Bender, University of Iowa
  • A. Ahmed
  • B. J. Smith
  • A. Button
  • Michael J. Goodheart, University of Iowa
Document Type
Article
Peer Reviewed
1
Publication Date
12-1-2012
NLM Title Abbreviation
Cancer Lett
PubMed ID
23268330
DOI of Published Version
10.1016/j.canlet.2012.12.016;
Abstract

We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation. Disease recurrence was increased with higher MVD in both unadjusted and adjusted analyses. In adjusted analysis, p53 null mutation was associated with increased recurrence and worse overall survival. Worse overall survival and increased recurrence risk were also associated with the combination of CD31 MVD values >25 vessels/HPF and any p53 mutation. P53 mutation status and MVD may have prognostic significance in patients with advanced-stage ovarian cancer. Tumors with p53 null mutations are likely to be more vascular, contributing to decreased survival and increased recurrence probability.

Published Article/Book Citation
Cancer letters, (2012) pp.
Disciplines
Citation Information
N. J. Nadkarni, Koen De Geest, T. Neff, B. D. Young, et al.. "Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer" Cancer letters (2012) ISSN: 1872-7980
Available at: http://works.bepress.com/david_bender/8/