This analysis measures the regional economic value of The University of Iowa Hospitals and Clinics (hereafter, UIHC). The assessment looks at UIHC operational expenditures using a properly specified regional input-output model that accurately reflects its major spending categories and its primary territory of economic influence. This analysis does not contain an estimate of the regional economic boost attributable to patients or the families of patients traveling to the Iowa City metropolitan area for services or other visits. An estimate of those values would require a scientifically valid survey of visitors and patients that details average duration of stay and the amount of spending accruing regionally. This study analyzes only the economic activity associated with the operation of the UIHC as a public health care institution.