Catheter-directed thrombolytic (CDT) therapy has steadily grown in popularity as the primary intervention for certain types of acute or subacute deep vein thrombosis. In such cases, nurses within the interventional radiology department must sustain patient care during all phases of the procedure while also monitoring progression of clot lysis and different CDT therapies used by the physician. This article describes the 3-day treatment and management of a patient presenting with extensive bilateral iliofemoral thrombosis. Relevant anatomy, indications for CDT therapy, and specific nursing considerations are reviewed.