Cytolytic peptides and proteins: Is there a common structural motif?Trends in Biochemical Sciences
ORCiDDavid M. Ojcius: 0000-0003-1461-4495
AbstractPore-forming proteins or peptides (PFP) have now been isolated from a wide array of species ranging from humans to bacteria. A great number of these toxins lyse cells through a ‘barrel-stave’ mechanism, in which monomers of the toxin bind to and insert into the target membrane and then aggregate like barrel staves surrounding a central, water-filled pore. An evaluation of the secondary structures suggests that common secondary structures may be employed by most of these toxic PFP.
Citation InformationDavid M. Ojcius and John Ding-E. Young. "Cytolytic peptides and proteins: Is there a common structural motif?" Trends in Biochemical Sciences Vol. 16 (1991) p. 225 - 229 ISSN: 0968-0004
Available at: http://works.bepress.com/david-ojcius/80/