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Article
Cytolytic peptides and proteins: Is there a common structural motif?
Trends in Biochemical Sciences
  • David M. Ojcius, Chang Gung University
  • John Ding-E. Young, Chang Gung University
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1016/0968-0004(91)90090-I
Publication Date
1-1-1991
Abstract
Pore-forming proteins or peptides (PFP) have now been isolated from a wide array of species ranging from humans to bacteria. A great number of these toxins lyse cells through a ‘barrel-stave’ mechanism, in which monomers of the toxin bind to and insert into the target membrane and then aggregate like barrel staves surrounding a central, water-filled pore. An evaluation of the secondary structures suggests that common secondary structures may be employed by most of these toxic PFP.
Citation Information
David M. Ojcius and John Ding-E. Young. "Cytolytic peptides and proteins: Is there a common structural motif?" Trends in Biochemical Sciences Vol. 16 (1991) p. 225 - 229 ISSN: 0968-0004
Available at: http://works.bepress.com/david-ojcius/80/