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Article
Cell death and inflammation during infection with the obligate intracellular pathogen, Chlamydia
Biochimie
  • Jean-Luc Perfettini, Université Paris
  • Veronique Hospital, Institut Pasteur
  • Lynn Stahl, Université Paris
  • Thomas Jungas, Université Paris
  • Philippe Verbeke, Université Paris
  • David M. Ojcius, Université Paris
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1016/j.biochi.2003.08.006
Publication Date
8-1-2003
Abstract
Infections by Chlamydia are followed by a strong inflammatory response, which is necessary to eliminate the infection, but at the same time is responsible for the pathology of infection. Resistance of infected cells against apoptosis induced by external ligands, together with the effects of IFNγ secreted during infection, would be expected to contribute to persistence of infection. Secretion of TNFα plays an important role during clearance of the chlamydiae, but also triggers apoptosis of uninfected cells in infected tissues. Apoptosis of infected host-cells towards the end of the infection cycle is thought to participate in the release of chlamydiae from infected cells and propagation of the infection. Dysregulation of the apoptotic program during infection leads to a less efficient infection, but paradoxically, results in a higher inflammatory response and more severe pathology.
Citation Information
Jean-Luc Perfettini, Veronique Hospital, Lynn Stahl, Thomas Jungas, et al.. "Cell death and inflammation during infection with the obligate intracellular pathogen, Chlamydia" Biochimie Vol. 85 Iss. 8 (2003) p. 763 - 769 ISSN: 0300-9084
Available at: http://works.bepress.com/david-ojcius/46/