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Article
At the innate frontiers between mother and fetus: linking abortion with complement activation
Immunity
  • Stephane M. Caucheteux, Jacques Monod Institute
  • Colette Kanellopoulos-Langevin, Jacques Monod Institute
  • David M. Ojcius, Pasteur Institute
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1016/S1074-7613(03)00028-1
Publication Date
2-1-2003
Abstract
The intricate mechanisms regulating fetomaternal interactions are still largely uncharacterized. Recent papers have revealed a major role for the innate immune system during abortion. Different experimental conditions—deletion of a complement regulator, injection of anti-phospholipid antibodies into mothers, or allorecognition of fetuses in the presence of an IDO inhibitor—all lead to complement activation, inflammation, and fetal loss. These observations also raise new questions on the relationship between the adaptive and innate systems during pregnancy.
Citation Information
Stephane M. Caucheteux, Colette Kanellopoulos-Langevin and David M. Ojcius. "At the innate frontiers between mother and fetus: linking abortion with complement activation" Immunity Vol. 18 Iss. 2 (2003) p. 169 - 172 ISSN: 1074-7613
Available at: http://works.bepress.com/david-ojcius/42/