At the innate frontiers between mother and fetus: linking abortion with complement activationImmunity
ORCiDDavid M. Ojcius: 0000-0003-1461-4495
AbstractThe intricate mechanisms regulating fetomaternal interactions are still largely uncharacterized. Recent papers have revealed a major role for the innate immune system during abortion. Different experimental conditions—deletion of a complement regulator, injection of anti-phospholipid antibodies into mothers, or allorecognition of fetuses in the presence of an IDO inhibitor—all lead to complement activation, inflammation, and fetal loss. These observations also raise new questions on the relationship between the adaptive and innate systems during pregnancy.
Citation InformationStephane M. Caucheteux, Colette Kanellopoulos-Langevin and David M. Ojcius. "At the innate frontiers between mother and fetus: linking abortion with complement activation" Immunity Vol. 18 Iss. 2 (2003) p. 169 - 172 ISSN: 1074-7613
Available at: http://works.bepress.com/david-ojcius/42/