Article
A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway.
Emerging Microbes and Infections
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
DOI
10.1038/s41426-018-0135-9
Publication Date
7-31-2018
Disciplines
Abstract
Leptospira interrogans is the major causative agent of leptospirosis, an emerging, globally spreading zoonotic infectious disease. The pathogen induces macrophage apoptosis, but the molecular basis and mechanism remain unknown. In the present study, we found that L. interrogans caused apoptosis of phagocytosis-inhibited macrophages, and the product of the L. interrogans LB047 gene (Lep-OMP047) was the unique protein captured by mouse and human Fas proteins. The recombinant expressed Lep-OMP047 (rLep-OMP047) strongly bound mouse and human Fas proteins with equilibrium association constant (K
Creative Commons License
Creative Commons Attribution 4.0 International
Citation Information
Peng Du, Shi-Jun Li, David M. Ojcius, Kai-Xuan Li, et al.. "A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway." Emerging Microbes and Infections Vol. 7 Iss. 1 (2018) p. 1 - 17 ISSN: 2222-1751 Available at: http://works.bepress.com/david-ojcius/241/