The role of P2 receptors in controlling infections by intracellular pathogensPurinergic Signalling
ORCiDDavid M. Ojcius: 0000-0003-1461-4495
AbstractA growing number of studies have demonstrated the importance of ATPe-signalling via P2 receptors as an important component of the inflammatory response to infection. More recent studies have shown that ATPe can also have a direct effect on infection by intracellular pathogens, by modulating membrane trafficking in cells that contain vacuoles that harbour intracellular pathogens, such as mycobacteria and chlamydiae. A conserved mechanism appears to be involved in controlling infection by both of these pathogens, as a role for phospholipase D in inducing fusion between lysosomes and the vacuoles has been demonstrated. Other P2-dependent mechanisms are most likely operative in the cases of pathogens, such as Leishmania, which survive in an acidic phagolysosomal-like compartment. ATPee may function as a ‘danger signal–that alerts the immune system to the presence of intracellular pathogens that damage the host cell, while different intracellular pathogens have evolved enzymes or other mechanisms to inhibit ATPe-mediated signalling, which should, thus, be viewed as virulence factors for these pathogens.
Citation InformationRobson Coutinho-Silva, Christiane Monteiro da Cruz, Pedro M. Persechini and David M. Ojcius. "The role of P2 receptors in controlling infections by intracellular pathogens" Purinergic Signalling Vol. 3 (2007) p. 83 - 90 ISSN: 1573-9538
Available at: http://works.bepress.com/david-ojcius/229/