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Article
The P2X7 receptor and intracellular pathogens: a continuing struggle
Purinergic Signalling
  • Robson Coutinho-Silva, Universidade Federal do Rio de Janeiro
  • Gladys Corrêa, Universidade Federal do Rio de Janeiro
  • Ali A. Abdul-Sater, University of California, Merced
  • David M. Ojcius, University of California, Merced
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Document Type
Article
DOI
10.1007/s11302-009-9130-x
Publication Date
6-1-2009
Abstract
The purinergic receptor, P2X7, has recently emerged as an important component of the innate immune response against microbial infections. Ligation of P2X7 by ATP can stimulate inflammasome activation and secretion of proinflammatory cytokines, but it can also lead directly to killing of intracellular pathogens in infected macrophages and epithelial cells. Thus, while some intracellular pathogens evade host defense responses by modulating with membrane trafficking or cell signaling in the infected cells, the host cells have also developed mechanisms for inhibiting infection. This review will focus on the effects of P2X7 on control of infection by intracellular pathogens, microbial virulence factors that interfere with P2X7 activity, and recent evidence linking polymorphisms in human P2X7 with susceptibility to infection.
Citation Information
Robson Coutinho-Silva, Gladys Corrêa, Ali A. Abdul-Sater and David M. Ojcius. "The P2X7 receptor and intracellular pathogens: a continuing struggle" Purinergic Signalling Vol. 5 (2009) p. 197 - 204 ISSN: 1573-9538
Available at: http://works.bepress.com/david-ojcius/219/