Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activityAntimicrobial Agents and Chemotherapy
ORCiDDavid M. Ojcius: 0000-0003-1461-4495
AbstractHydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
Citation InformationAli A. Abdul-Sater, David M. Ojcius and M. P. Meyer. "Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity" Antimicrobial Agents and Chemotherapy Vol. 52 Iss. 7 (2008) p. 2660 - 2662 ISSN: 0066-4804
Available at: http://works.bepress.com/david-ojcius/216/